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Our EEG Guided rTMS approach is an innovative and targeted treatment based on powerful third-party research published in the most prestigious scientific journals. Below, you will find the peer-reviewed and published research regarding EEGs and rTMS that builds the foundation of our approach to brain treatment.
Autism Studies
“A recent review was done, focused on published research studies using TMS to treat ASD between 2018 and 2023. These were systematically reviewed to study characteristics, specific parameters of TMS, localization techniques and stimulus targets, behavioral outcomes, and neuroimage biomarker changes. It was extensive and you can see the full study here:
“After TMS intervention, discernible enhancements across a spectrum of scales are evident in stereotyped behavior, repetitive behavior, and verbal social domains. A comprehensive review of literature spanning the last five years demonstrates the potential of TMS treatment for ASD in ameliorating the clinical core symptoms.
“Recent findings generally indicate that TMS has positive effects on stereotypical behavior, repetitive behavior, verbal and social aspects of ASD, leading to overall improvement across all scale scores post-intervention.
“Transcranial magnetic stimulation (TMS) is a promising, emerging tool for the study and potential treatment of ASD. Recent studies suggest that TMS measures provide rapid and noninvasive pathophysiological ASD biomarkers. Furthermore, repetitive TMS (rTMS) may represent a novel treatment strategy for reducing some of the core and associated ASD symptoms.
“While its true potential in ASD has yet to be delineated, TMS represents an innovative research tool and a novel, possibly transformative approach to the treatment of neurodevelopmental disorders.
“Repetitive TMS affords researchers to design specific stimulation protocols that can modulate neuroplasticity, and such neuroplasticity-based brain stimulation interventions look promising.”
“Existing evidence still indicates that aberrant neuroplasticity could play a critical role in the pathogenesis of ASD. Therefore, it can be postulated that it may be possible to attain optimal social and cognitive performance in ASD by stabilizing aberrant neuroplasticity. In this context, we discussed a novel mechanism-driven approach toward achieving such goal using rTMS. If successful, this information will not only help us better understand the brain mechanisms involved in ASD but also stimulate trials testing mechanism-driven novel brain stimulation treatment paradigms for ASD.”
“The results of our systematic review and meta-analysis data indicate that TMS may offer a promising and safe treatment option for pediatric and young adult patients with IC-ASD.”
“Several rTMS trials in ASD have shown marked improvements in motor symptomatology, attention and perceptual binding.
“Conclusion: rTMS is the first therapeutic attempt at ASD aimed at correcting some of its core pathology.”
“TMS is a non-invasive therapeutic intervention capable of modulating evoked and induced gamma oscillations and altering maladaptive behaviors83. Recent reviews of the literature suggest that TMS is safe and effective when used in ASD.”
“Our findings suggest that HF [high frequency] rTMS over the left parietal cortex might improve core deficits in low-functioning children with ASD.”
“Repetitive transcranial magnetic stimulation (rTMS) emerges as a useful therapy for autism spectrum disorder (ASD) clinically.”
“The results showed the hyper-variability in the resting-state networks of ASD patients, while three week rTMS treatment alleviates the hyper fluctuations occurring in the frontal-parietal and frontal-occipital connectivity and further contributes to the ameliorative ASD symptoms. In addition, the changes in variability network properties are closely correlated with clinical scores, which further serve as potential predictors to reliably track the long-term rTMS efficacy for ASD.Significance.The findings consistently demonstrated that the temporal variability of time-varying networks of ASD patients could be modulated by rTMS, and related variability properties also help predict follow-up rTMS efficacy, which provides the potential for formulating individualized treatment strategies for ASD”
“The findings of this study demonstrate that high-frequency rTMS over the parietal lobe is potentially an effective strategy to improve core symptoms by enhancing long-range connectivity reorganization in ASD.”
“rTMS provides changes in connectivity and behavior, suggesting its potential use as a viable treatment option for ASD individuals.”
“Our results suggest that rTMS, particularly after 18 sessions, facilitates cognitive control, attention and target stimuli recognition by improving discrimination between task-relevant and task-irrelevant illusory figures in an oddball test. The noted improvement in executive functions of behavioral performance monitoring further suggests that TMS has the potential to target core features of ASD.”
“There was a statistically significant clinical improvement in patients receiving active TMS comparing baseline Childhood Autism Rating Scale (CARS) assessment and after treatment.
“There was significant difference in improvement between the two groups according to eye contact. There was significant improvement in response to examiner.
“There was significant difference in improvement between the two groups according to active expressive language.
“Conclusion: Repetitive transcranial magnetic stimulation (rTMS) over left inferior frontal gyrus may be a safe and effective way of improving language of ASD. The joint application of rTMS and standard language therapy may lead to more rapid improvement in the language progress of children with ASD.”
“These findings supported our hypothesis by demonstration of positive effects of combined rTMS neurotherapy in active treatment group as compared to the waitlist group, as the rTMS group showed significant improvements in behavioral and functional outcomes as compared to the waitlist group.”
“Conclusion: This study presents evidence on the efficacy and safety of α-rTMS in improving ASD symptoms, quality of life and comorbid sleep troubles in children. However, these findings should be interpreted as preliminary pending the presentation of double-blind, randomised clinical trials.”
“Given our understanding of the EEG and the consistent abnormalities in the electrophysiology of children with ASD, we would suggest that MRT [MeRT] is an appropriate therapeutic option to further pursue. The existing literature in depression and posttraumatic stress disorder in addition to preliminary studies in children with ASD all support its potential impact as a therapeutic option.”
“Following 5 weeks of EEG-EKG guided transmagnetic stimulation, significant changes in symptom severity and EEG measures are reported for 28 children with autism spectrum disorder. … This suggests that EKG-EEG guided TMS may be effective at mitigating averse sensory misperceptions common in ASD.”